VAI TRÒ CỦA CỦA ĐÁNH GIÁ TẾ BÀO HỌC TỨC THÌ ĐỐI VỚI NỘI SOI PHẾ QUẢN SIÊU ÂM TRONG CHẨN ĐOÁN TỔN THƯƠNG HẠCH VÙNG TRUNG THẤT

Abstract

Objective: This study aimed to evaluate the role of Rapid On-Site Evaluation (ROSE) over Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS – TBNA) in rapid, accurate diagnosis and adequate sample collection for mediastinal lymph node lesions. Materials and Methods: A retrospective study on 83 EBUS – TBNA cases was performed at University Medical Center Ho Chi Minh City from December 2022 to January 2024. The main variables of the study were procedure time, concordance between cytological and pathological diagnosis, and number of cells collected after each procedure. Results: Compared with the final pathology results, the sensitivity, specificity, and accuracy of ROSE were 84.9%, 92.7%, and 88.4%, respectively. The concordance between ROSE and pathology diagnosis was reduced in cases where multiple lymph node biopsies were performed during the same procedure. 92% of cases had more than 100 tumor cells, which was sufficient for PD-L1 testing and other molecular tests. Conclusion: ROSE provided diagnostic results with high concordance with final Pathology results, with a concordance rate of 88.4%. Nearly all cases with malignant diagnoses had sufficient cells for PD-L1 and molecular testing.