Article Sidebar
Views pdf: 29
EFFICACY OF ORAL TERBINAFINE IN COMBINATION WITH KETOCONAZOLE BATHS IN THE TREATMENT OF TINEA CORPORIS
Main Article Content
Abstract
Tinea corporis is quite common in Vietnam, caused by dermatophytes. Treatment requires a combination of topical and systemic antifungal drugs. This study was conducted to evaluate the efficacy of oral terbinafine combined with ketoconazole baths in the treating of tinea corporis. This was a clinical intervention study without a control group, before-after comparison, prospective. There were 59 patients participating in the study. The results showed that after 4 weeks of treatment, 47 patients were completely cured, accounting for 79.6%. The rate of disease improvement decreased and the rate of no cure both accounted for 10.2%. After treatment, there were no patients with severe disease. The rate of moderate lesions decreased from 57.6% before treatment to 20.3% after treatment. The rate of mild lesions increased from 8.5% before treatment to 79.7% after treatment, p < 0.05. The rate of positive fungal test was 10.2%, lower than that before treatment (100%), with p < 0.05. Undesirable effects after treatment included dry skin (3.4%), dizziness, itching and flatulence (each accounting for 1.7%).
Article Details
Keywords
Tinea corporis, dermatophyte, terbinafine, ketoconazole, antifungal drugs
References
2. Bhatia V.K., Sharma P.C. (2014), Epidemiological studies on Dermatophytosis in human patients in Himachal Pradesh, India, Springer Plus, 3, 134.
3. Vũ Văn Tiến (2015), “Đặc điểm lâm sàng bệnh nhân mắc nấm da khám và điều trị tại bệnh viện 103 (2013 – 2014), Báo cáo khoa học toàn văn, hội nghị ký sinh trùng toàn quốc lần thứ 42, NXB. Khoa học tự nhiên và công nghệ, tr.180 – 186.
4. Nguyễn Thái Dũng, Lê Trần Anh, Nguyễn Khắc Lực (2017). Nghiên cứu một số đặc điểm và kết quả điều trị nấm da ở bệnh nhân đến khám và điều trị tại trung tâm chống Phong-Da liễu Nghệ An 2015-2016. Tạp chí Y Dược học Quân sự, 2:118-125.
5. Shivakumar V. et al (2011), “Intermittent Pulse-Dosed Terbinafin in the Treatment of Tinea corporis and/or Tinea Cruris”, Indian J Dermatol, 56(1), 121 – 122.
6. Voravutinon V. (1993), “Oral Treatment of Tinea corporis and Tinea Cruris with Terbinafin and Griseofulvin”, J Med Assoc Thai, 76(7), 388-393.
7. Sharma P., Bhalla M., Thami G.P. et al (2019), Evaluation of efficacy and safety of oral terbinafin and itraconazole combination therapy in the management of dermatophytosis, Journal of Dermatological Treatment, 1-5.
8. Cole GW, Stricklin G. A comparison of a new oral antifungal, terbinafin, with griseofulvin as therapy for tinea corporis. Arch Dermatol. 1989;125:1537–9.
9. Kumar Amit, Budania Navin, Sharma Priyamvada, et al. A comparative study of efficacy of terbinafin and fluconazole in patients of tinea corporis. Int J Pharm Med & Bio Sc. 2013;2(4):92-98.
10. Bhatia A, Kanish B, Badyal D, et al. Efficacy of oral terbinafin versus itraconazole in treatment of dermatophytic infection of skin: A prospective, randomized comparative study. Indian Journal of Pharmacology. 2019;51(2):116-119.