KHẢO SÁT SỰ TĂNG SINH VÀ DI CƯ CỦA NGUYÊN BÀO SỢI TẠI KHOA RĂNG HÀM MẶT, ĐẠI HỌC Y DƯỢC THÀNH PHỐ HỒ CHÍ MINH

Abstract

Introduction: Wound healing is a complex and multifactorial process that is difficult to predict. Fibroblasts play a crucial role in wound healing by maintaining and repairing connective tissues. In Vietnam, several studies have investigated the proliferation and migration of fibroblasts derived from periodontal ligaments, gingiva, dental papilla, and dental pulp. Further evaluation of the proliferative and migratory capacity of fibroblasts derived from palatal tissue could provide valuable insights for both basic research and therapeutic applications. Objectives: To assess the proliferation and migration capacity of human fibroblasts derived from palatal soft tissue in vitro. Materials and methods: Fibroblasts from palatal soft tissue were obtained from the research group at the Laboratory of Oral and Maxillofacial Biology, University of Medicine and Pharmacy at Ho Chi Minh City. The proliferation and migration of palatal-derived fibroblasts were evaluated at days 1, 3, 5, 7, 9, and 11, as well as at 0h, 8h, 24h, and 48h. Results: Line 5 exhibited the highest proliferation, significantly surpassing Line 3 and Line 4 at days 7 and 9 (p < 0.0001) before declining at day 11. Line 5 also showed the fastest wound closure, followed by Line 4 and Line 3. Conclusion: Fibroblasts from younger individuals demonstrated superior proliferation and migration, indicating age-related differences in wound healing capacity.