ĐẶC ĐIỂM VI SINH HỌC VÀ TÌNH TRẠNG ĐỀ KHÁNG KHÁNG SINH TRÊN BỆNH NHÂN NHIỄM KHUẨN ĐƯỜNG TIẾT NIỆU NHẬP VIỆN ĐIỀU TRỊ TẠI BỆNH VIỆN PHỤC HỒI CHỨC NĂNG – ĐIỀU TRỊ BỆNH NGHỀ NGHIỆP

Abstract

Target: Survey on antibiotic resistance rate of bacteria agents causing urinary tract infections in inpatients at Hospital for Rehabilitation and Professional Diseases. Object of study and methods: Cross- sectional descriptive study on 117 patients treated at Hospital for Rehabilitation and Professional Diseases from March 2023 to August 2023. Results: E. coli is the most common pathogen (n=44), followed by Klebsiella (n=24), Enterobacter (n=23), Proteus (n=10), Pseudomonas (n=13), Acinobacter (n=2), Gram positive bacteria (n=1). E. coli is about 94% resistant to Cephalosporin antibiotics and resistant to other antibiotics with rate ranging from 43% to 95%; E.coli is still highly susceptible to fosfomycin and colistin. Klebsiella is resistant to most antibiotics including cephalosporin, amikacin and quinolone. Its resistance rate to meropenem is 37.5% and 79.3% to imipenem. Klebsiella is still highly susceptible to colistin. Enterobacter is resistant to most experimental antibiotics with rate ranging from 34.8% to 100% and has low resistance to colistin and fosfomycin. Pseudomonas was resistant to most antibiotic commonly used in clinical trials and about 100% sensitive to colistin. Proteus is resistant to most antibiotics including Cephalosporin, Quinolone, Amikacin, Fosfomycin and highly resistant to colistin (80.0%). When examining Carbapenem antibiotics, Proteus is still highly sensitive to Meropenem with resistance rate of 20%. Conclusion: The clinical characteristics of UTI in patients at HCMC Hospital for Rehabilitation and Professional Diseases are often atypical, most of which manifest as fever. E. coli is the most common agent. Most of the agents causing UTI are highly resistant to quinolone and cephalosporin antibiotics. Fosfomycin is one of the antibiotics considered for the treatment of UTI patients in the hospital who have previously used antibiotics.