KHẢO SÁT MỐI LIÊN QUAN GIỮA GENOTYPE VÀ TÌNH TRẠNG KHÁNG CLARITHROMYCIN CỦA HELICOBACTER PYLORI Ở BỆNH NHÂN VIÊM LOÉT DẠ DÀY TÁ TRÀNG

Abstract

Background: Clarithromycin resistance is increasing worldwide and is the most common cause of Helicobacter pylori treatment failure. Objectives: This study aims to determine the rate of clarithromycin resistance of Helicobacter pylori in patients with inflammation, gastric ulcer - duodenal ulcer and the relationship between genotype and clarithromycin resistance of Helicobacter pylori. Materials and methods: This cross-sectional study was conducted on peptic ulcer patients in Tien Giang province from May 2020 to May 2021. Participants were interviewed, clinically examined, and collected samples of gastrointestinal mucosa. Patients were identified as Helicobacter pylori infection by gram stain, possitive urease test or positive culture microbiology test in Helicobacter pylori. Clarithromycin resistance in Helicobacter pylori was determined by E-test method and determined genotype by Realtime-PCR technique. Results: The rate of clarithromycin resistance of Helicobacter pylori in patients participating in the study was 77.3%. The group of patients infected with the Helicobacter pylori strain carrying the cagA(+) genotype had a higher rate of antibiotic resistance than the group of patients infected with the Helicobacter pylori strain carrying the cagA(-) genotype, with an OR (95%CI): 11.25 (1.11-114.37), p=0.024. Conclusions: Helicobacter pylori cagA(+)-positive patients should receive special attention because of their increased resistance to clarithromycin.