ĐA HÌNH RS1746048 GEN CXCL12 Ở BỆNH NHÂN NHỒI MÁU CƠ TIM CẤP TẠI BỆNH VIỆN ĐA KHOA TỈNH SÓC TRĂNG

Abstract

Background: Myocardial infarction creates a burden for both the healthcare system and patients with a significantly increased risk of death due to cardiac and extracardiac events. The rs1746048 polymorphism has the potential to affect the activity and expression of the CXCL12 gene, thereby affecting physiological and pathological processes in the myocardium, including acute myocardial infarction. Objectives: Study on polymorphism characteristics of rs1746048 CXCL12 gene in patients with acute MI. Materials and methods: Cross-sectional descriptive study on 70 patients with acute MI at Soc Trang Provincial General Hospital. Results: The study recorded 70 patients with acute MI, with a higher proportion of male patients than female patients. The majority of patients were ≥ 60 years old with 75.7%. Risk factors in patients with acute MI included high rates of hypertension (80%) and smoking (64.3%). The most common electrocardiographic abnormalities were T wave abnormalities (98.6%), ST elevation (55.7%) and pathological Q wave (47.1%). The CC genotype had the highest rate with 54.3% and the TT had the lowest rate (10%). The C allele had a higher rate than the T allele (72.1% and 27.9%). The study did not record differences in gender, age group and some cardiovascular risk factors - history with genotype distribution in patients with acute MI. Conclusion: Patients with acute myocardial infarction recorded the C allele and CC genotype as dominant with rates of 72.1% and 54.3%, respectively. The genetic model with the rate of CT + TT and CC accounted for an equal rate (45.7% and 54.3%).