ĐẶC ĐIỂM LÂM SÀNG VÀ CẬN LÂM SÀNG BỆNH VIÊM MÀNG NÃO NHIỄM KHUẨN DO ESCHERICHIA COLI Ở TRẺ NHŨ NHI TẠI BỆNH VIỆN NHI TRUNG ƯƠNG

Abstract

Objective: To describe the clinical and laboratory test characteristics of meningitis caused by Escherichia coli in infants. Methods: Cross-sectional study was conducted in 30 patients with Escherichia coli (E. coli) meningitis at the National Children's Hospital from July 2020 to December 2024. Results: 70% children got E. coli meningitis was in newborns and those under 3 months of age. The common clinical symptoms were fever (86.7%) and poor feeding (70%). 50% of patients had abnormal white blood cell count; 63.4% of patients had CRP >100 mg/l. Prevalence of elevated white blood cell (>1000 cells/mm³) and protein (>1 g/L) in cerebrospinal fluid was 56.7% and 76.7%, respectively. Brain CT/MRI showed subdural effusion/pus in 56.7%; rate of ventricular dilatation and brain parenchymal lesions was 30% and 16.7%, respectively. 76,7% patients had antibiotic susceptibility analysis with meronem sensitive rate was100%. Prevalence of ceftriaxone, cefotaxim, ciprofloxacin and gentamycin resistance was 65.2%; 73.9%; 34.8% và 13.3%. 100% was resistant to ampicillin and cefuroxime. Conclusion: Meningitis caused by Escherichia coli is a serious central nervous system infection commonly found in infants and young children with high antibiotic resistance, affecting treatment outcomes and increasing the risk of neurological complications.