KẾT QUẢ ĐIỀU TRỊ TRỨNG CÁ TRUNG BÌNH VÀ NẶNG BẰNG UỐNG ISOTRETINOIN KẾT HỢP BÔI AZELAIC ACID 20%

Abstract

Acne is a common skin disease, often seen in adolescents, the disease has little impact on health but greatly affects aesthetics, psychology and quality of life. This clinical intervention study with a controlled group was conducted to evaluate the results of treating moderate and severe acne with oral isotretinoin combined with topical azelaic acid 20%. Patients participating in the treatment were randomly assigned to two groups, each group had 30 patients. Group 1 was treated with oral isotretinoin 20 mg/day combined with topical azelaic acid 20%; group 2 was treated with oral isotretinoin 20 mg/day. The results showed that after 12 weeks of treatment, the number of inflammatory lesions in group 1 decreased better than that in group 2 (0.77 vs. 2.10; p < 0.05), the acne severity score (Global Acne Grading System, GAGS ) in group 1 (1.2) was lower than that in group 2 (2.9; p < 0.05). The rate of acne outbreak (mild level) after 4 weeks in group 1 was lower than that in group 2 (20% vs. 36.7%); after 12 weeks of treatment, there was no outbreak in either group. Treatment of moderate and severe acne with oral isotretinoin combined with topical azelaic acid 20% was effective in reducing the number of lesions and severity. The main side effects were dry skin and dry lips, but they gradually decreased over time.