ĐẶC ĐIỂM LÂM SÀNG VÀ CẬN LÂM SÀNG CỦA TRẺ BỊ BỆNH THIẾU HỤT HORMON TĂNG TRƯỞNG (GH) TẠI BỆNH VIỆN ĐA KHOA XANH PÔN HÀ NỘI

Abstract

Background: Growth hormone (GH- somatropin) is peptide hormone secreted by the anterior lobe of the pituitary gland. It stimulates the growth of the body, height and weight in children. Growth hormone deficiency is a rare disorder disease. It results in growth retardation, short stature and maturation delays reflected by the delay of lengthening of the bones... Children need to be detected and treated early to improve their final height and help them confidently integrate into life. Objective: To analyze and describe clinical, para clinical features in children with growth hormone deficiency (GH) at Saint Paul Hospital. Research subjects: 47 children who meet the criteria for diagnosis of GH deficiency are being treated as outpatients at Saint Paul l Hospital. Research method: Case-series study. Results: 100% short stature. Facial abnormalities, typically caused by pituitary defects: 19/47. Boy with small penis and small testicular: 12/31. 100% of children have bone age lower than actual age < -2SD, mean value: 2,61 ± 2.2 years. MRI of the head is 82,9% normal. GH stimulation test showed that 93.6% of children had a complete deficiency of GH hormone, 6,4% of children with moderate growth deficiency. Conclusion: Children with slow growth rate, stunting, short stature combined with GH stimulation test (+), bone age lower than actual age are the criteria to diagnose children with GH hormone deficiency.