CLINICAL AND HISTOPATHOLOGICAL FEATURES 135 CUTANEOUS MELANOMA PATIENTS AT K HOSPITAL PERIOD 2016 - 2024
Main Article Content
Abstract
Objective: Study clinical and histopathological features of 135 cutaneous melanoma patients at K Hospital. Methods: Study cutaneous melanoma patients with primary tumors, diagnosed and surgeried at K Hospital. Results: Common age from 40 to 60 years old, female/male = 1.01, farmers 56.4%, disease duration over 6 months 66.2%, big moles 34.1%, lower limb 49.6%, keratinized skin base 43.0%, sharp pain 43.7%, black tumor 65.9%, superficial spreading 52.6%, Clark V 46.7%, vertical growth phase 72.6%, mitotic rate > 6/mm2 38.5%, satellite 34.8%, ulcer 48.1%, sparse infiltrating lymphocytes 46.7%, vascular invasion 77.8%, regional lymph node metastasis 48.1%, intermediate lymph node metastasis 5.9%, pT3 41.5%, pT4 54.8%, pN0 51.9%, stage II, III 51.9% and 48.1%. Conclusion: Female/male = 1.01. Common clinical features: from 40 to 60 years old, farmers, disease duration over 6 months, moles and keratinized, in the lower limbs especially in the soles of the feet, sharp pain, sharp pain, black tumor, regional lymph node metastasis. Common histopathological features: superficial spreading, increase of thickness, increase of invasion, vertical growth phase, increase of mitotic rate, vascular invasion, tumor ulcer.
Article Details
Keywords
Clinical features, histopathological features,, cutaneous melanoma
References

2. Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. 2022;71(3):209-249.

3. Shen W, Sakamoto N, Yang L. Melanoma-specific mortality and competing mortality in patients with non-metastatic malignant melanoma: a population-based analysis. BMC cancer. 2016;16:413.

4. Adler NR, Haydon A, McLean CA, Kelly JW, Mar VJ. Metastatic pathways in patients with cutaneous melanoma. Pigment cell & melanoma research. 2017;30(1):13-27.

5. Garbe C, Büttner P, Bertz J, et al. Primary cutaneous melanoma. Identification of prognostic groups and estimation of individual prognosis for 5093 patients. Cancer. 1995;75(10):2484-2491

6. Bartoli C, Bono A, Clemente C, Del Prato ID, Zurrida S, Cascinelli N. Clinical diagnosis and therapy of cutaneous melanoma in situ. Cancer. 1996;77(5):888-892.

7. Đào Thị Thúy Hằng. Đặc điểm giải phẫu bệnh và một số yếu tố mô bệnh học mang ý nghĩa tiên lượng trong ung thư hắc tố da. Hà Nội Luận văn thạc sỹ y học, Đại học Y Hà Nội; 2017.

8. Balch CM, Soong SJ, Gershenwald JE, et al. Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2001;19(16):3622-3634.

9. Mandalà M, Imberti GL, Piazzalunga D, et al. Clinical and histopathological risk factors to predict sentinel lymph node positivity, disease-free and overall survival in clinical stages I-II AJCC skin melanoma: outcome analysis from a single-institution prospectively collected database. European journal of cancer (Oxford, England : 1990). 2009;45(14):2537-2545.
