NGHIÊN CỨU SỰ BIẾN ĐỔI NỒNG ĐỘ PROPOFOL TRONG NÃO VÀ TRONG HUYẾT TƯƠNG DƯỚI HƯỚNG DẪN CỦA CHỈ SỐ LƯỠNG PHỔ BIS TRONG PHẪU THUẬT UNG THƯ TUYẾN GIÁP

Abstract

Objective: To evaluate the variation in target concentration of propofol in the brain and plasma under the guidance of the Bispectral Index (BIS) during thyroid cancer surgery. Subjects and Methods: A total of 82 patients diagnosed with thyroid cancer, undergoing treatment at the Thoracic Surgery Department of 108 Military Central Hospital, and indicated for near-total or total thyroidectomy from September 2023 to February 2024, were included in the study. Results: The average induction time for anesthesia in the study group was 5.28±0.82 minutes, with a minimum of 4 minutes and a maximum of 9 minutes. The propofol dosage was 6.61±0.65 mg/kg/h. At time point T1, Ce (effect-site concentration) and Cp (plasma concentration) increased, while BIS decreased. Cp was higher than Ce, with a statistically significant difference (p<0.005) at T1 and T3. Differences in Cp and Ce at other time points were not statistically significant. Cp was highest at T1, while Ce peaked at T2. Ce values ranged from 2.7 to 3.3 µg/mL, and Cp values ranged from 2.8 to 3.9 µg/mL. BIS remained within the range of 40–60 throughout anesthesia. Conclusion: The Bispectral Index (BIS) is an effective tool for monitoring anesthetic depth and adjusting propofol concentration during thyroid cancer surgery.