MỐI TƯƠNG QUAN GIỮA TẢI LƯỢNG HBV DNA VÀ NỒNG ĐỘ ALT Ở BỆNH NHÂN VIÊM GAN VIRUS B MẠN ĐIỀU TRỊ TENOFOVIR

Abstract

Objective: This study aims to investigate the correlation between HBV DNA load and ALT levels in patients with chronic hepatitis B undergoing Tenofovir treatment. Methods: A cross-sectional study was conducted on 250 patients treated at the University Medical Center Ho Chi Minh City from November 2020 to May 2021. Data on HBV DNA load and ALT levels were collected and analyzed. Results: The average age of patients was 45 ± 12 years, with 60% male and 40% female. The mean HBV DNA load was 3.2 log10 IU/ml, with 20% of patients having HBV DNA < 2.0 log10 IU/ml, 48% between 2.0 and 3.9 log10 IU/ml, and 32% ≥ 4.0 log10 IU/ml. The mean ALT level was 45 IU/ml, with 32% of patients having ALT < 40 IU/ml, 48% between 40 and 79 IU/ml, and 20% ≥ 80 IU/ml. A moderate positive correlation was found between HBV DNA load and ALT levels (r = 0.35, p < 0.001). The correlation was stronger in patients with HBV DNA ≥ 3.0 log10 IU/ml (r = 0.42, p < 0.001) and ALT ≥ 45 IU/ml (r = 0.39, p < 0.001). HBeAg-positive patients (40%) showed higher HBV DNA and ALT levels compared to HBeAg-negative patients (60%). Conclusion: There is a moderate positive correlation between HBV DNA load and ALT levels in chronic hepatitis B patients. Higher HBV DNA loads are associated with increased liver damage, as reflected by elevated ALT levels. These findings support the use of both HBV DNA and ALT as important markers in the management and monitoring of chronic hepatitis B patients.