SCREENING OF BK VIRUS LOAD IN PLASMA AND URINE IN FIRST THREE MONTHS IN KIDNEY TRANSPLANT PATIENTS AT 103 MILITARY HOSPITAL

Toản Phạm Quốc, Đức Nguyễn Văn, Nhật Võ Văn, Sử Hoàng Xuân, Bền Nguyễn Hữu, Phương Nguyễn Minh, Giang Ngô Trường, Thắng Lê Việt, Vân Diêm Thị, Hà Nguyễn Thị Thu, Xuân Nguyễn Thanh

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Abstract

Objectives: This study aims to investigate BK viral loads in plasma and urine within three months after kidney transplantation. Patients and methods: A total of 80 patients who underwent kidney transplantation in the Organ Transplant Center, Military Hospital 103. Quantification of BK virus was performed using realtime – PCR at month 1, 2 and 3. Results and Discussion: Among 80 recipients of kidney transplants analyzed. The rate of BK viremia at months 1, 2 and 3 was 2.47%; 4.94% and 9.88%, respectively. The corresponding rate of BK virus in urine infection was 28.4%; 17.28% and 18.52%, respectively. The distribution of BK viral loads in blood and urine was related to the time of BK virus reactivation with a higher rate was observed at month 3 as compared with those at month 1 and 2 (p<0,001). There was no association between age, gender and glomerular filtration rate with the time of BK virus reactivation (p>0,05). BK virus loads in urine at month 3 were an independent risk factor for predicting the presence of BK viremia. Conclusion: This study indicated that prevalence of BK virus in blood and urine was highest at month 3 among recipients of renal transplant in Vietnam. The surveillance of BK virus within 3 months after transplantation helps to monitor and make appreciate therapeutic intervention for kidney transplant recipients.

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References

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