ĐA HÌNH rs37972 TRÊN GEN GLCCI1 Ở BỆNH NHÂN NHI HEN PHẾ QUẢN TẠI BỆNH VIỆN NHI ĐỒNG CẦN THƠ

Abstract

Background: Asthma is a common chronic respiratory disease in children, posing a burden on healthcare systems, families, and asthma patients worldwide. The rs37972 polymorphism may influence the activity and expression of the GLCCI1 gene, thereby affecting asthma treatment processes. Objective: To investigate the frequency of the rs37972 polymorphism in the GLCCI1 gene in children with asthma. Materials and methods: A cross-sectional study was conducted on 58 pediatric asthma patients at Can Tho Children's Hospital. Results: Among the 58 patients, the proportion of males was higher than females. Patients from other provinces accounted for 53.4%. The most common asthma-related factors were allergen exposure (43.1%) and a history of COVID-19 infection (41.4%). Children with level 2 asthma accounted for 69.0% of the study participants. The CT genotype was the most common (65.5%), while the TT genotype was the least common (12.1%). The C allele was more prevalent than the T allele (55.2% and 44.8%). The study did not record differences in gender, residence, disease severity, and some related factors with genotype distribution in children with asthma. Conclusion: Pediatric asthma patients predominantly carried the C allele and the CT genotype, with frequencies of 55.2% and 65.5%, respectively. The genetic model shows that the CT + TT genotypes are three times more prevalent than the CC genotype (77.6% and 22.4%).