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Date Published: 23/12/2021
Abstract Views: 104
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DOI: https://doi.org/10.51298/vmj.v507i2.1416
Issue
Vol. 507 No. 2 (2021)
Section
Các bài báo
How to Cite
Thị Quyên, L. ., Huy Anh, B. ., Đức Phấn, T. ., & Thị Trang, N. . (2021). INVESTIGATION OF SOD2 C47T POLYMORPYSISM AND CAT C262T POLYMORPHISM IN MEN WITH PRIMARY INFERTILITY. Vietnam Medical Journal, 507(2). https://doi.org/10.51298/vmj.v507i2.1416

INVESTIGATION OF SOD2 C47T POLYMORPYSISM AND CAT C262T POLYMORPHISM IN MEN WITH PRIMARY INFERTILITY

Lê Thị Quyên1, Bạch Huy Anh2, Trần Đức Phấn1, Nguyễn Thị Trang1,
1 Hanoi Medical University
2 Hospital of Post and Telecommunications

Main Article Content

Abstract

Objectives: Identification of the prevalence of SOD2 C47T polymorphism and CAT C262T polymorphism in primary infertilite men, initial determination of the association between SOD2 C47T polymorphism and C262T CAT polymorphism with male infertility. Subjects and methods: Application of ARMS-PCR in determining SOD2 C47T polymorphism and CAT C262T polymorphism for 42 primary infertile men whose semen concentration less than 15 million sperm/ml and 58 healthy men with at least 1 child aged less than 5 years old. Results: In the group of infertile men, the cases with genotype SOD2 CC/TC/TT are 28.5%, 40.5%, 31%, respectively, in the control group, the cases with genotype SOD2 CC/TC/TT are 29.3%, 46.6%, 24.1%, respectively, the difference between the 2 groups is not statistically significant with p>0.05, OR=; in the group of infertile men, the men withgenotype CAT CC/TC/TT are 54.7%,42.9% and 2.4%, respectively;in the control group the cases with genotype CAT CC/TC/TT are 77.6%, 19%, 3,4%, respectively; the difference between the 2 groups was statistically significant with p<0.05. Conclusion: There was no association between the SOD2 C47T gene polymorphism and the risk of male infertility, the risk of infertility in the men with CAT C262T polymorphism is 2.86 times higher than healthy men.

Article Details

Keywords

Male infetility, SOD2, CAT

References

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