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CONSTRUCT THE MODEL OF COST-EFFECTIVENESS ANALYSIS OF PEMBROLIZUMAB VERSUS STANDARD THERAPY IN THE TREATMENT OF NON- SMALL CELL LUNG CANCER IN VIETNAM
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Abstract
Cost-effectiveness analysis is a tool used to aid decisions about which medical care should be offered, in which constructing model is considered one of the most important steps. Pembrolizumab (PEM) was recognized by the Food and Drug Administration (FDA) in 2016 as the first-line drug in the treatment of non-small cell lung cancer (NSCLC). However, the high price of drug has been creating a large barrier in using this drug in practice, especially in developing countries like Vietnam. It is necessary to consider the feasibility of drug selection in clinical practice based on cost - effectiveness analysis. With modeling research method combined with literature review and indepth-interview with clinical experts, the cost – effectiveness analysis model has been built based on Microsoft Excel 2013 software with model structure including calculation pages for outcome parameters (Incremental cost – effectiveness ratio (ICER), Sensitivity analysis). The model allows to evaluate the cost – effectiveness of PEM monotherapy versus chemotherapy in the treatment of NSCLC in Vietnam.
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Keywords
Cost-effectiveness, model, pembrolizumab, non-small cell lung cancer
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