MỐI LIÊN QUAN GIỮA NỒNG ĐỘ KHÁNG THỂ TRAB VỚI MỘT SỐ ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG TRONG BỆNH GRAVE’S Ở TRẺ EM

Abstract

Grave’s disease is one of the most common primary hyperthyroidism among patients with thyrotoxicosis. Serum TRAb level, along with clinical and biochemical indicators, contributes to the prognosis of the disease. Objective: Describe the relationship between serum TRAb level and some clinical and biochemical characteristics of Grave’s disease in children. Subjects: 58 children diagnosed with Grave's disease at Vietnam National Children's Hospital from January 2021 to November 2024. Methods: Cross-sectional, retrospective, prospective. Results: The female: male ratio was 41/17 (2.4:1) with a mean age of 9.6 ± 3.1 years. TRAb level at the time of diagnosis, end of induction treatment and maintenance phase were: 22.4 ± 11.3, 15.6 ± 11.4, and 8.8 ± 8.1 U/L, respectively. There was no difference in TRAb level between two groups: under 10 years old and 10-18 years old. TRAb level of the group with grade 2-3 goiter was significantly higher than that in the group with grade 1 goiter at the time of diagnosis, end of induction treatment and maintenance phase (p<0.05). There was an inverse correlation between TRAb index and TSH index in the maintenance phase with a correlation coefficient of 0.47. Conclusion: TRAb level was higher in the group with grade 2-3 goiter compared to the group with grade 1 goiter, TRAb level was inversely correlated with serum TSH level in the maintenance phase. Recommendation: Clinicians need to comprehensively assess the level of goiter, monitor biochemistry including serum FT4, T3, TSH and TRAb levels during the monitoring process to make accurate clinical decisions and effectively treat children with medicine.