ĐẶC ĐIỂM BỆNH NHÂN U LYMPHO KHÔNG HODGKIN Ở NGƯỜI LỚN TẠI VIỆN HUYẾT HỌC–TRUYỀN MÁU TRUNG ƯƠNG GIAI ĐOẠN 2019-2023

Abstract

Non-Hodgkin's lymphoma (NHL) is a group of diseases with complicated progression due to malignant lymphoid proliferation. This is a common group of diseases in hematology, the number is increasing. NHL is a group of diseases that are clinically and biologically very diverse, including slowly progressing to rapidly progressing forms. Clinical and paraclinical features play an important role in diagnosis, treatment and prognosis of lymphoma. Objective: To survey the clinical and paraclinical characteristics of NHL in adults at the National Institute of Hematology and Blood Transfusion. Subjects: 800 adult NHL patients at the National Institute of Hematology and Blood Transfusion from January 2019 to July 2023. Research method: cross-sectional description with prospective and retrospective. Results: The average age was 54.63 ± 15.87 years; The ratio of men is higher than that of women (1.5:1). The majority of B cell lymphoma 80.4%, diffuse large B-cell lymphoma (DLBCL) 55.3%; T cells lymphoma and T/NK cells lymphoma 19.6%. In 643 B-cell patients, the CD20 (+) rate accounted for 97.5%. The most common clinical symptom is lymph node enlargement (55.4%). 38.8% of patients have syndrome B. Extranodal lesions account for 57.1%. Location of damage: in the testicles, the central nervous system meets DLBCL mainly (>90%); In the nose and sinuses T/NK is mainly (67.6%), in the Custaneous lymphoma mainly T cells (90%). As for other positions, DLBCL accounts for 40-80%. Patients are mainly in stages III and IV (26.1% and 37%). 39.2% anemia; 13.9% thrombocytopenia. 20.9% marrow invasion. The rate of marrow invasion in the slowly progressing disease is lower than aggressive lymphomas (p < 0.05), mantle cell lymphoma (MCL) and small cell lymphoma (SLL) is higher than other B-cell lymphoma subtypes. T cells lymphoma and T/NK cells lymphoma had higher serum B2M levels than other (p<0.05).