KHẢO SÁT NỒNG ĐỘ HORMONE TUYẾN CẬN GIÁP TRÊN BỆNH NHÂN SUY THẬN MẠN LỌC MÁU CHU KỲ TẠI KHOA THẬN NHÂN TẠO – BỆNH VIỆN CHỢ RẪY

Abstract

Secondary hyperparathyroidism is quite common in patients with end-stage chronic kidney disease, affecting the patient's healthcare and reducing the effectiveness of treatment. Objectives: This study aims to investigate the serum parathyroid hormone (PTH), calcium and inorganic phosphorus concentrations in patients with chronic kidney disease undergoing regular hemodialysis at Cho Ray Hospital from March 2022 to December 2023. Subjects and Methods: Cross-sectional analysis research was applied on 123 patients with chronic kidney disease undergoing cyclic hemodialysis at the Hemodialysis Department, Cho Ray Hospital. Patients who had used phosphate binders, calcium, or PTH-lowering drugs in the past three months were excluded. Serum PTH levels were measured using the chemiluminescent immunoassay (CLIA) method, and other biochemical parameters such as calcium, inorganic phosphorus, eGFR, and β2-microglobulin were also collected and assessed. Results: The average serum PTH level was 348.99 pg/mL. The percentage of patients with serum PTH levels higher than 300 pg/mL was 43.93%. There was an inverse correlation between concentrations of serum PTH and eGFR (p < 0.001) and a positive correlation between PTH and β2-microglobulin (r = 0.44, p < 0.001). No significant correlation was found between PTH and calcium, phosphate, or the Ca × P product. Conclusion: The study shows that serum PTH levels are correlated with eGFR and β2-microglobulin, indicating that PTH may be an important factor in monitoring and managing patients with chronic kidney disease undergoing hemodialysis.