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Date Published: 06/06/2025
Abstract Views: 180
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DOI: https://doi.org/10.51298/vmj.v550i3.14349
Issue
Vol. 550 No. 3 (2025)
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Các bài báo
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Nguyễn Nhật, H., Trần Kế, T., Nguyễn Thị Thu, T., Trang Thanh, N., Huỳnh Võ Mai, Q., & Lê Cao Minh, C. (2025). CORRELATION BETWEEN THE GANGLION CELL-INNER PLEXIFORM LAYER THICKNESS AND MACULAR VISUAL FIELD SENSITIVITY MEASURED WITH 24-2C HUMPHREY VISUAL FIELD IN PRIMARY OPEN-ANGLE GLAUCOMA PATIENTS. Vietnam Medical Journal, 550(3). https://doi.org/10.51298/vmj.v550i3.14349

CORRELATION BETWEEN THE GANGLION CELL-INNER PLEXIFORM LAYER THICKNESS AND MACULAR VISUAL FIELD SENSITIVITY MEASURED WITH 24-2C HUMPHREY VISUAL FIELD IN PRIMARY OPEN-ANGLE GLAUCOMA PATIENTS

Hãn Nguyễn Nhật, Tổ Trần Kế, Tâm Nguyễn Thị Thu, Nghiệp Trang Thanh, Quyên Huỳnh Võ Mai, Châu Lê Cao Minh

Main Article Content

Abstract

Purpose: To assess and compare the macular structure-function (S-F) relationship derived from the 22 and 12 test points within the central 10 degrees visual field (VF) area using the 24-2C test in eyes with primary open-angle glaucoma. Method: We enrolled 95 eyes of 32 healthy and 63 glaucomatous subjects in this cross-sectional study, approved by Research Ethics Committee of Ho Chi Minh City Medicine and Pharmacy University, No 22786–ĐHYD. Macular ganglion cell-inner plexiform layer thicknesses (mGCIPLT) at different parafoveal locations were measured using Cirrus HD-OCT 5000. The mean sensitivity (MS) of 24-2C and 24-2 VFs was recorded in the decibel. The topographic relationships between structure and function were assessed at different parafoveal and hemimacular locations according to the map of Garway-Heath and colleagues. The strength of S-F relationships between macular ganglion cell-inner plexiform layer thickness measurements and VF mean sensitivity in various parafoveal locations and in superior and inferior hemimacula was compared. Results: There were significant global and sectoral correlations between the mGCIPLT and VFMS using both VF grids. The S-F correlations between the average/hemimacular mGCIPLT and the corresponding VFMS using a 24-2C grid were however significantly greater in glaucoma groups (p<0.05). The 24-2C grid showed significantly greater S-F associations in the average, superior, inferior hemifield, superotemporal and inferotemporal parafoveal sectors than the 24-2 VF grid (p<0.05). Conclusion: The 24-2C visual field grid may provide more valuable information than 24-2 visual field grid for understanding the structure–function relationships of the macular region and may likely enhance the detection of subtle central VF defects in glaucoma.

Article Details

Keywords

24-2C, visual field, macular structure-function relationship, optical coherence tomography, macular ganglion cell-inner plexiform layer, open angle glaucoma

References

1. Weinreb RN, Leung CK, Crowston JG, et al. Primary open-angle glaucoma. Nat Rev Dis Primers. Sep 22 2016;2:16067.
2. Harwerth RS, Carter-Dawson L, Shen F, Smith EL, 3rd, Crawford ML. Ganglion cell losses underlying visual field defects from experimental glaucoma. Invest Ophthalmol Vis Sci. Sep 1999;40(10):2242-50.
3. De Moraes CG, Hood DC, Thenappan A, et al. 24-2 Visual Fields Miss Central Defects Shown on 10-2 Tests in Glaucoma Suspects, Ocular Hypertensives, and Early Glaucoma. Ophthalmology. Oct 2017;124(10):1449-1456.
4. Gedde SJ, Vinod K, Wright MM, et al. Primary Open-Angle Glaucoma Preferred Practice Pattern®. Ophthalmology. Jan 2021;128(1):P71-p150.
5. Hong JW, Baek MS, Lee JY, Song MK, Shin JW, Kook MS. Comparison of the 24-2 and 24-2C Visual Field Grids in Determining the Macular Structure-Function Relationship in Glaucoma. J Glaucoma. Oct 1 2021;30(10):887-894.
6. Mwanza JC, Oakley JD, Budenz DL, Chang RT, Knight OJ, Feuer WJ. Macular ganglion cell-inner plexiform layer: automated detection and thickness reproducibility with spectral domain-optical coherence tomography in glaucoma. Invest Ophthalmol Vis Sci. Oct 21 2011;52(11):8323-9.
7. Wang DL, Raza AS, de Moraes CG, et al. Central Glaucomatous Damage of the Macula Can Be Overlooked by Conventional OCT Retinal Nerve Fiber Layer Thickness Analyses. Transl Vis Sci Technol. Nov 2015;4(6):4.
8. Kim S, Lee JY, Kim SO, Kook MS. Macular structure-function relationship at various spatial locations in glaucoma. Br J Ophthalmol. Oct 2015;99(10):1412-8.
9. Lee JW, Morales E, Sharifipour F, et al. The relationship between central visual field sensitivity and macular ganglion cell/inner plexiform layer thickness in glaucoma. Br J Ophthalmol. Aug 2017;101(8):1052-1058.
10. Park SC, Kiumehr S, Teng CC, Tello C, Liebmann JM, Ritch R. Horizontal central ridge of the lamina cribrosa and regional differences in laminar insertion in healthy subjects. Invest Ophthalmol Vis Sci. Mar 21 2012;53(3):1610-6.