MỘT SỐ YẾU TỐ LIÊN QUAN VÀ HẬU QUẢ CỦA HIỆN TƯỢNG TĂNG NỒNG ĐỘ TROPONIN I ĐỘ NHẠY CAO TRONG SỐC NHIỄM KHUẨN

Abstract

Introduction: The factors associated with and the consequences of elevated high-sensitivity troponin I (hs-TnI) levels in septic shock remain unclear. Objectives: To investigate common factors associated with hs-TnI elevation and its relationship with clinical outcomes in patients with septic shock. Methods: A cross-sectional descriptive study was conducted on 136 patients diagnosed with septic shock based on the Sepsis-3 definition, admitted to the Intensive Care Unit of Hoan My Cuu Long Hospital from January 2023 to October 2024. Results: The prevalence of hs-TnI elevation at diagnosis was 61% after gender adjustment, with a median level of 36 ng/L (interquartile range: 10.0 – 175.9). Factors associated with hs-TnI elevation included positive blood cultures, SOFA score at diagnosis, serum procalcitonin, and hemoglobin levels. In multivariate analysis, serum procalcitonin remained significantly associated with hs-TnI elevation (OR = 1.005, 95% CI: 1.001 – 1.010, p = 0.020). hs-TnI elevation was associated with an increased rate of mechanical ventilation (56.6% vs. 32.1%, p = 0.009), higher in-hospital mortality (41% vs. 22.6%, p = 0.044), and higher 30-day mortality (48.2% vs. 28.3%, p = 0.034). Conclusion: Serum procalcitonin is a factor associated with hs-TnI elevation in patients with septic shock in multivariate analysis. Elevated hs-TnI levels are associated to increased mechanical ventilation requirements and higher mortality rates.