EFFECTIVENESS OF PREOPERATIVE CHEMORADIOTHERAPY AND SPHINCTER PRESERVING SURGERY FOR RECTAL CANCER (T3-T4)

Đỗ Tất Cường1,, Bùi Vinh Quang1, Hoàng Mạnh Thắng2, Nịnh Thị Thảo1, Nguyễn Hoàng Gia1, Võ Quốc Hoàn1, Trần Quang Kiên1, Nguyễn Hoài Nam1, Phạm Anh Đức1
1 Hanoi Oncology Hospital
2 K Hospital

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Abstract

Objective: To evaluate the efficiency of preoperative chemoradiotherapy and sphincter-preserving surgery for patients with locally advanced distal rectal cancer. Patients and methods: Description study of 44 patients with locally advanced distal rectal cancer who had received preoperative chemoradiotherapy and sphincter-preserving surgery between May 2016 and May 2021. Results: According the pathologic examination of rescted specimens in patients who had received neo-adjuvant chemoradiotherapy, complete pathologic response was observed in 9,1%, 52,3% showed near complete pathologic response. The mean disease free survival (DFS) was 45,16±3,51months. DFS rates of 1 year, 2 years and 3 years were respectively 97%, 77,4% and 68,3%. Conclusion: Preoperative chemoradiotherapy and sphincter preserving surgery is the cornerstone and effective treatment in locally advanced distal rectal cancer.

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References

1. Globocan. Colorectal cancer incidence and mortality worldwide in 2018. International agency for research on cancer. 2018
2. Elwanis MA, Maximous DW, Elsayed MI, Mikhail NN. Surgical treatment for locally advanced lower third rectal cancer after neoadjuvent chemoradiation with capecitabine: prospective phase II trial. World journal of surgical oncology. Jun 9 2009
3. Phạm Cẩm Phương. Đánh giá hiệu quả của xạ trị kết hợp capecitabine trước mổ trong ung thư trực tràng thấp tiến triển tại chỗ. Luận án Tiến sỹ. Trường Đại học Y Hà Nội; 2013
4. Phạm Khánh Toàn. Nhận xét một số đặc điểm lâm sàng, cận lâm sàng và kết quả xạ trị gia tốc tăng phân liều trước mổ ung thư trực tràng giai đoạn T3-T4. Luận văn Thạc sỹ y học. Trường Đại học Y Hà Nội; 2013
5. HammadTeama A, AbdelsamieAlarabawy R,

AbdelhadyMohamed H, HanyEissa H. The Egyptian Journal of Radiology and Nuclear Medicine. ScienceDirect. 2015;46(4):833- 846.
6. Sun YS, Li XT, Zhang XY, Tang L, Cui Y, Zhang XP. [Preoperative staging of rectal carcinoma with high-resolution MRI: correlation with histopathologic findings]. Zhonghua wai ke za zhi [Chinese journal of surgery]. Mar 2012; 50(3):207-10.
7. Võ Văn Xuân, Nguyễn Đại Bình, Ngô Vĩ Dung. Nghiên cứu áp dụng kỹ thuật xạ trị gia tốc tăng phân liều tiền phẫu kết hợp với phẫu thuật ung thư trực tràng. Tạp chí Ung thư học Việt Nam. 2012; 2:57-66.
8. Kim JC, Kim TW, Kim JH, et al. Preoperative concurrent radiotherapy with capecitabine before total mesorectal excision in locally advanced rectal cancer. International journal of radiation oncology, biology, physics. Oct 1 2005;63(2):346-53.
9. Chamlou R, Parc Y, Simon T, et al. Long-term results of intersphincteric resection for low rectal cancer. Annals of surgery. Dec 2007;246(6):916-21; discussion 921-2.