ĐẶC ĐIỂM LÂM SÀNG, NỘI SOI VÀ MÔ BỆNH HỌC CỦA NGƯỜI 18 – 50 TUỔI BỊ U TUYẾN ĐẠI TRỰC TRÀNG NGUY CƠ CAO

Abstract

Objective: This study aimed to describe the clinical, endoscopic, and histopathological features of colorectal advanced adenomas (CAAs) in individuals aged 18 to 50 years. Subjects and methods: A prospective cross-sectional study involving 150 patients diagnosed with CAAs was conducted at the GI Endoscopy Department, University Medical Center, Ho Chi Minh City, between January 2, 2023, and December 31, 2023. CAAs were defined as adenomas exhibiting at least one of the following criteria: size ≥10 mm, villous component ≥25% (tubular or tubulovillous adenoma), or high-grade dysplasia. Results: The median age was 44 years, with 68.67% being male. Approximately one-third of patients presented with alarm symptoms, and only 10% reported a family history of colorectal cancer. A single CAA was identified in 87.33% of cases. CAAs was most commonly identified in the sigmoid colon. The vast majority (98.67%) of CAAs were diagnosed based on a lesion size of ≥10 mm. The proportions of adenomas with villous components ≥ 25% and high-grade dysplasia were 19.33% and 7.33%, respectively. Conclusion: In this cohort of adults aged 18 to 50 years with CAAs, alarm symptoms were observed in approximately one-third of patients, and adenomas exhibiting a villous component ≥ 25% or high-grade dysplasia were relatively uncommon.