ẢNH HƯỞNG CỦA SARCOPENIA ĐẾN TÌNH TRẠNG PHỤ THUỘC HOẠT ĐỘNG THỂ CHẤT VÀ CHẤT LƯỢNG CUỘC SỐNG Ở BỆNH NHÂN LỌC MÁU CHU KỲ

Abstract

Objective: To analyze the impact of sarcopenia on physical dependency and quality of life in hemodialysis patients after 12 months of follow-up. Subjects and methods: A prospective, observational, longitudinal study was conducted on hemodialysis patients. The Asian Working Group for Sarcopenia 2019 definition was applied for diagnosis. Logistic regression and linear regression analyses were used to evaluate the impact of sarcopenia on physical dependency and quality of life after 12 months of follow-up. Results: Among the 270 participants, 45.2% had sarcopenia. Multivariate logistic regression analysis showed that reduced muscle mass (OR 2.997; 95% CI: 1.008–8.913; p = 0.048), decreased handgrip strength (OR 3.657; 95% CI: 1.360–9.831; p = 0.01), sarcopenia (OR 4.658; 95% CI: 1.396–15.545; p = 0.012), and severe sarcopenia (OR 4.307; 95% CI: 1.229–15.097; p = 0.022) were risk factors for reduced IADL. Multivariate linear regression analysis indicated that reduced muscle mass (B = -0.044; p = 0.021), decreased handgrip strength (B = -0.04; p = 0.017), and severe sarcopenia (B = -0.058; p = 0.015) were associated with decreased quality of life rating. Conclusion: In hemodialysis patients, sarcopenia, along with its components such as reduced muscle mass and decreased handgrip strength, are risk factors for physical dependency and reduced quality of life.