TREATMENT OUTCOMES AND PROGNOSTIC FACTORS OF FAVOURABLE HISTOLOGIC TYPES IN EARLY STAGE BREAST CANCER AT VIETNAM NATIONAL CANCER HOSPITAL

Linh Nguyễn Thị Lý, Đức Lê Thanh

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Abstract

We aimed to assess treatment outcomes and prognostic factors of favourable  histologic types in early stage breast cancer at Vietnam National Cancer Hospital. Materials and Method: Retrospective study on medical records of 30 cases diagnosed at early breast cancer from 2019 to 2025 in Vietnam National Cancer Hospital, pathological diagnosis are mucinous carcinoma, cribriform carcinoma or tubular carcinoma. We analyzed disease free survival (DFS),  overall survival (OS) and some relative factors to survival. Results: There were 30 cases including: 43.3% of mucinous carcinoma. Patients’ mean age was 56.3 (range: 38-82 years old). The mean follow-up time was 33,2±21,1 months (from 5.5 to 79.1), we found one recurrent patient. The 5-year DFS was 88.9%. Survival based on stage I, II and III were 100&, 100% and 50%. The five-year OS was 100%. Althoung age, high disease stage, positive lymph node involvement showed lower 5-year DFS, these were not statistically significant. Conclusion: Favourable histologic types are uncommon in breast carcinoma. These subtypes have an excellent prognosis with relatively high OS and DFS. We did not find the relation between prognostic factors and survival.

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References

1. Fattaneh AT, Peter D. WHO Classifcation Pathology and Genetics of Tumours of the Breast and Female Genital Organs. IARC Press, Lyon, France; 2003.
2. F. Cardoso SK, S. Ohno, F. Penault-Llorca, P. Poortmans, I. T. Rubio, S. Zackrisson & E. Senkus, on behalf of the ESMO Guidelines Committee. Early Breast Cancer. ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. 2019.
3. Goetz MP, Gradishar WJ, Anderson BO, Abraham J, Aft R, Allison KH, et al. Journal of the National Comprehensive Cancer Network : JNCCN. 2019;17(2):118–26.
4. Lam, A.H.K.; Co, M.T.H.; Kwong, A. Rare Breast Cancer Histotypes Retrospective Study and Literature Review. J. Clin. Med. 2024, 13, 643. https://doi.org/ 10.3390/jcm13030643.
5. Makki J. Diversity of Breast Carcinoma: Histological Subtypes and Clinical Relevance. Clin Med Insights Pathol. 2015 Dec 21;8:23-31. doi: 10.4137/CPath.S31563. PMID: 26740749; PMCID: PMC4689326.
6. Samitharapanya, S. (2010). Favorable Histologic Type Breast Cancer in Lampang Hospital; Clinical Presentation and Outcome.
7. Zhang H, Zhang N, Moran MS, Li Y, Liang Y, Su P, Haffty BG, Yang Q. Special subtypes with favorable prognosis in breast cancer: A registry-based cohort study and network meta-analysis. Cancer Treat Rev. 2020 Dec;91:102108. doi: 10.1016/j.ctrv.2020.102108. Epub 2020 Oct 9. PMID: 33075683.