MỨC ĐỘ ĐA ĐỀ KHÁNG KHÁNG SINH CỦA MỘT SỐ VI KHUẨN GRAM ÂM THƯỜNG GẶP TẠI BỆNH VIỆN ĐA KHOA THÀNH PHỐ CẦN THƠ TỪ NĂM 2022 – 2023

Abstract

Backround: The treatment of Gram-negative bacteria is increasingly complicated by the rise of multidrug resistance strains of Gram-negative bacilli. Objective: Determining the level of multiple antibiotic resistance of Gram-negative bacteria strains isolated at Can Tho City General Hospital. Materials and method: Common Gram-negative bacteria strains were isolated from clinical specimens at Can Tho City General Hospital. Results: Multidrug resistance Gram-negative bacteria accounted for the highest proportion of 76.2%, in the group ≤ 40 years old (83.3%) from pus and urine specimens (87.4%) and (81.6%). Extensive-drug resistance was found in many sputum samples (41.2%). Multidrug resistance strains account for the highest proportion in the ICU 60.2% and Endocrinology 86.6%. The rate of multidrug resistance is highest in Proteus mirabilis (95%), Escherichia coli (93.3%). Kleibsiella pneumoniae accounts for the highest proportion of extensive-drug resistance bacteria strains (44.4%) and pandrug resistance strains (6%), followed by Acinetobacter baumannii which has a high proportion of extensive-drug resistance bacteria strains (41.5%). All had statistically significant differences (p<0.001). Conclusion: The rationale for the use of antibiotic combinations is that mortality from Gram-negative bacteremia is increased when patients receive inappropriate initial antibiotic therapy. Our study recommends that narrowing the antibacterial spectrum based on culture results will preserve the broadest spectrum of agents to treat multidrug resistance pathogens