SỰ ĐỀ KHÁNG KHÁNG SINH CỦA VI KHUẨN ESCHERICHIA COLI TRÊN CÁC MẪU BỆNH PHẨM CỦA BỆNH NHÂN ĐƯỢC CHỈ ĐỊNH LÀM KHÁNG SINH ĐỒ TẠI BỆNH VIỆN ĐA KHOA THÀNH PHỐ CẦN THƠ

Abstract

Background: In Vietnam, the increasing prevalence of antibiotic resistance in Escherichia coli has become an alarming issue that adversely affects the efficacy of clinical treatments. Objectives: This study aimed to determine the infection rate and assess the antibiotic resistance patterns of Escherichia coli isolated from clinical specimens designated for antimicrobial susceptibility testing at Can Tho City General Hospital. Materials and Methods: A retrospective analysis was conducted using a convenience sample until a total of 419 isolates were obtained. Clinical specimens—including sputum, blood, urine, pus, and other samples—were collected from patients, cultured, isolated, and identified according to the procedures recommended by the Ministry of Health (2007). Results: The majority of Escherichia coli isolates were obtained from blood (33.9%) and urine (26.2%). The isolates exhibited high resistance to antibiotics in the ß-Lactam and Quinolone groups, while remaining highly sensitive to Ertapenem (82.5%), Imipenem (84.8%), and Amikacin (96.3%); however, resistance to Gentamicin was notably higher (49.4%). Resistance rates for most antibiotic groups did not differ significantly between the two study years (2023 and 2024), except for Amikacin (p < 0.05). Notably, the Internal Medicine department showed the highest resistance rates, particularly for the ß-Lactam group. Conclusions: Escherichia coli exhibited high resistance to several antibiotics, especially β-lactams, while remaining susceptible to Amikacin, Imipenem, and Ertapenem.