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RESULTS OF CONCURRENT CHEMORADIOTHERAPY WITH ETOPOSIDE - CISPLATIN REGIMEN AND INTENSITY MODULATE RADIATION IN STAGE III NON - SMALL CELL LUNG CANCER
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Abstract
Objectives: To evaluate the treatment results of EP regimen combined with dose-modulated radiotherapy in stage III non-small cell lung cancer and describe some undesirable effects of the treatment regimen. Patients and methods: 37 patients with stage III NSCLC who received chemotherapy and radiotherapy concurrently with intensity modulated radiation therapy and etoposide-cisplatin chemotherapy regimen at K Hospital from January 2019 to June 2021. Results: Study group characteristics: Mean age 57, men account for 86,5%, selected patients were in good performance status with 22 (59,5%) in 37 ECOG 0 patients. Stage host disease mainly stage IIIB accounts for 62.2%, histopathology is mainly adenocarcinoma 64.9%. Treatment results: Evaluation of response according to RECIST 1.1 showed that the rate of complete and partial response was 2,7% and 83,8%, respectively. Progression-free survival was 14 ± 3,7 months. Progression-free survival at 12 months 54,7% was Toxicity: There were 24,3% pneumonia patients, 44,2% esophagitis patients only grade I, II. Toxicity on hematopoietic system mainly grade I, II., only 2.7% of patients appeared grade III. Toxicity on liver, kidney, vomiting, fatigue, weight loss are at 1-2 levels. Conclusion: The regimen not only gave good results in terms of response rates and progression-free survival, but also significantly reduced radiation-related toxicity
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Keywords
Lung cancer, concurrent chemoradiotherapy, EP, response rate, toxicity
References
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