KHẢO SÁT NỒNG ĐỘ VÀ XÁC ĐỊNH MỐI TƯƠNG QUAN GIỮA CYSTATIN C VÀ HORMONE TUYẾN GIÁP Ở BỆNH NHÂN CƯỜNG GIÁP

Abstract

Background: Serum cystatin C levels have been suggested to be associated with thyroid function parameters and may serve as a monitoring tool in the treatment of hyperthyroidism. However, existing data remains inconsistent, particularly in Vietnam. Objective: To investigate the serum levels of cystatin C and determine the correlation between cystatin C and thyroid hormones. Materials and methods: This descriptive, cross-sectional study with analysis included 63 patients diagnosed with hyperthyroidism who sought treatment at Binh Thuan Provincial General Hospital from September 2024 to March 2025. Results: The female-to-male ratio was 3.85, with a mean age of 44.59 ± 13.08 years, most of whom were under 50 years old. The average body mass index (BMI) was 20.0 ± 3.35, and 41.3% of patients were classified as underweight. The median serum levels of FT3, FT4, and TSH were 3.58 pmol/L, 1.38 pmol/L, and 0.215 mUI/L, respectively. The average cystatin C level was 0.82 ± 0.19 mg/L. A positive correlation was found between cystatin C levels and FT3 (r = 0.666; p < 0.001) and FT4 (r = 0.447; p < 0.001). Conversely, cystatin C levels showed a negative correlation with TSH (r = -0.526; p < 0.001). Conclusion: Serum cystatin C levels show a positive correlation with serum FT3 and FT4 levels and a negative correlation with serum TSH levels.