VAI TRÒ CỦA KHOẢNG THỜI GIAN TPEAK – TEND TRONG PHÂN TẦNG NGUY CƠ Ở BỆNH NHÂN CÓ ĐIỆN TÂM ĐỒ DẠNG BRUGADA

Abstract

Background: Brugada syndrome is one of the serious arrhythmias, which may cause syncope or sudden death. The standard 12-lead electrocardiogram (ECG) is usually used to detect Brugada syndrome. Nowaday, the utility of electrophysiology for the risk stratification of sudden death for patients with Brugada ECG pattern has been controversial regarding sensitivity and specificity. Tpeak-Tend interval and Tpeak-Tend/QT ratio, which are measured by using the surface ECG, can predict the risk of arrhythmias. Objectives: (1) Investigate the Tpeak-Tend interval and the Tpeak-Tend/QT ratio in patients with Brugada ECG pattern. (2) Evaluate Tpeak-Tend interval and the Tpeak-Tend/QT ratio as the risk stratification of ventricular arrhythmias in these patients. Subjects and methods: A descriptive cross-sectional study on 41 patients with Brugada ECG pattern from Vietnam National Heart Institute - Bach Mai Hospital. The patients were indicated for electrocardiogram, echocardiogram, basic blood test, and taken personal and family history. Seeking the relationship by comparing the measurement results on the standard 12-lead electrocardiogram with the results of EP. Results: 41 patients (95,1% male) with Brugada ECG pattern participating in the study had an average age of 49 ± 11 years old. EPS was positive in 58.55% (24 patients), which induced the ventricular tachycardia, ventricular fibrillation. The Tpeak-Tend interval was significantly longer in the positive EPS group than in the EP negative group. Conclusions: Tpeak-Tend interval and Tpeak-Tend/QT ratio were significantly higher in leads V1 and V2 in Brugada patients, who had an life-threatening ventricular arrhythmia during EPS.