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Date Published: 25/06/2025
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DOI: https://doi.org/10.51298/vmj.v551i2.14579
Issue
Vol. 551 No. 2 (2025)
Section
Các bài báo
How to Cite
Nghiêm Xuân, H., Nguyễn Thị, L., & Mai Thanh, B. (2025). EVALUATING THE ROLE OF ANTIBIOTICS AND DRAINAGE IN THE TREATMENT OF LIVER ABSCESS IN THE SITUATION OF HIGH PREVALENCE OF KLEBSIELLA PNEUMONIAE. Vietnam Medical Journal, 551(2). https://doi.org/10.51298/vmj.v551i2.14579

EVALUATING THE ROLE OF ANTIBIOTICS AND DRAINAGE IN THE TREATMENT OF LIVER ABSCESS IN THE SITUATION OF HIGH PREVALENCE OF KLEBSIELLA PNEUMONIAE

Hoàn Nghiêm Xuân, Loan Nguyễn Thị, Bình Mai Thanh

Main Article Content

Abstract

Objective: This study evaluates the effectiveness of three treatment strategies for liver abscesses: antibiotic monotherapy, combination antibiotic therapy, and combination therapy with abscess drainage. Methods: A retrospective study was conducted on 196 patients diagnosed with liver abscesses at the 108 Military Central Hospital from 2018 to 2023. Clinical, microbiological, and treatment data were analyzed using SPSS 20.0. Treatment response rates were compared using the Chi-square test, while recovery time was analyzed using Kaplan-Meier curves and the Log-rank test. Results: Klebsiella pneumoniae was the most common causative pathogen (80.9%). The highest treatment response rate was observed in the combination therapy with the abscess drainage group (84.3%), followed by the combination antibiotic therapy group (76.9%) and the antibiotic monotherapy group (70%). However, differences were not statistically significant (p > 0.05). Notably, 18.9% of patients required adjustments to their antibiotic regimen during treatment. The drainage group experienced the shortest pain recovery time, and fever resolution might have been prolonged, but the analysis did not reach statistical significance. Conclusion: Despite the lack of statistical significance, combining antibiotics with abscess drainage demonstrated a trend towards improved response rates and recovery time. The high prevalence of Klebsiella pneumoniae (80.9%) and the substantial rate of antibiotic regimen changes (18.9%) underscore the complexity of liver abscess management in Vietnam. Prospective studies with larger sample sizes are needed to optimize treatment strategies in this local context. 

Article Details

Keywords

Liver abscess, treatment, antibiotics, combination therapy, abscess drainage, clinical outcomes

References

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