TÌNH HÌNH VÀ MỘT SỐ YẾU TỐ LIÊN QUAN TĂNG ACID URIC MÁU Ở BỆNH NHÂN THOÁI HÓA KHỚP GỐI NGUYÊN PHÁT TẠI BỆNH VIỆN ĐA KHOA THỐNG NHẤT ĐỒNG NAI

Abstract

Background: Hyperuricemia is a common metabolic disorder associated with various forms of arthritis, including primary knee osteoarthritis (PKOA). However, in Vietnam, only a limited number of small-scale studies have focused on this condition in the elderly population. Objective: To determine the prevalence and associated factors of hyperuricemia in patients with PKOA. Materials and methods: A cross-sectional descriptive study with an analytical component was conducted on 202 patients diagnosed with PKOA at Thong Nhat General Hospital, Dong Nai. Results: The female-to-male ratio was approximately 3:1, with a mean age of 65.68 ± 13.36 years and an average BMI of 23.76 ± 3.49 kg/m². Common comorbidities included dyslipidemia (87.6%), hypertension (56.4%), and diabetes mellitus (23.3%). The prevalence of hyperuricemia in PKOA patients was 29.2%. The most frequently reported clinical symptoms were knee pain (100%), restricted joint mobility (76.1%), morning stiffness (59.7%), and knee crepitus (51.7%). The most common radiographic sign was osteophyte formation (100%), with the majority of cases classified as Kellgren-Lawrence grade 2 (63.4%). Male sex was significantly associated with hyperuricemia (OR = 2.95, 95% CI: 1.51–5.74, p = 0.001). Additionally, hypertension (OR = 3.45, 95% CI: 1.74–6.83) and chronic kidney disease (OR = 3.45, 95% CI: 1.59–7.51) were found to be related to hyperuricemia. Furthermore, VAS and WOMAC scores were significantly associated with hyperuricemia (p < 0.001). Conclusion: Hyperuricemia is prevalent among PKOA patients. Male sex, hypertension, and chronic kidney disease are significant associated factors. Additionally, VAS and WOMAC scores show a statistically significant correlation with hyperuricemia.