A CASE OF LEPTOSPIRA INFECTION COMPLICATED BY ACUTE RENAL FAILURE AND BRADYARRHYTHMIA
Main Article Content
Abstract
We report a case of a 9-year-old male patient with Leptospira infection complicated by acute renal failure and bradyarrhythmia, diagnosed and treated at the Department of General Internal Medicine, Hanoi Children's Hospital. The patient, residing in Hanoi, presented with bradycardia, edema, hematuria, hypertension, and signs of renal failure. Upon taking the medical history, we discovered that the patient lived in a household with many domestic animals, including dogs, cats, and notably, white rats. Laboratory tests confirmed Leptospira as the causative agent. The patient was diagnosed with acute renal failure and bradyarrhythmia due to Leptospira infection. He was treated with Doxycycline and supportive therapies. After 7 days of treatment, the patient's symptoms improved, with no further signs of arrhythmia or renal dysfunction. The patient was discharged and scheduled for outpatient follow-up.
Article Details
Keywords
Leptospira infection, acute renal failure, cardiac arrhythmia
References
2. Chaikajornwat J, Rattanajiajaroen P, Srisawat N, et al. Leptospirosis manifested with severe pulmonary haemorrhagic syndrome successfully treated with venovenous extracorporeal membrane oxygenation. BMJ Case Reports CP, 2020;13:e230075.
3. Pothuri, Pallavi et al. Leptospirosis Presenting with Rapidly Progressing Acute Renal Failure and Conjugated Hyperbilirubinemia: A Case Report. The American journal of case reports vol. 17 567-9.
4. Assimakopoulos SF, Michalopoulou S, Papakonstantinou C, et al. A case of severe sinus bradycardia complicating anicteric leptospirosis. Am J Med Sci. 2007;333(6):381-3.
5. Werts C, Tapping RI, Mathison JC, et al. Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism. Nat Immunol. 2001;2(4):346-352.
6. Knuefermann P, Sakata Y, Baker JS, et al. Toll-like receptor 2 mediates Staphylococcus aureus-induced myocardial dysfunction and cytokine production in the heart. Circulation. 2004;110(24):3693-3698.
7. Dai RP, Dheen ST, Tay SS. Induction of cytokine expression in rat post-ischemic sinoatrial node (SAN). Cell Tissue Res. 2002;310(1):59-66.
8. Daschner C, Schübler AS, Jung M, et al. Severe Leptospirosis with Acute Kidney Injury: A Case Description and Literature Review. Nephron. 2024;148(11-12):832-839.