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THE VALUE OF SENTINEL LYMPH NODE SCINTIGRAPHY WITH GAMMA PROBE GUIDANCE IN BREAST CANCER SURGERY
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Abstract
Objective: To evaluate the clinical utility of sentinel lymph node (SLN) scintigraphy using Technetium-99m (99mTc) labeled sulfur colloid in combination with intraoperative gamma probe guidance in breast cancer surgery. Materials and Methods: From August 2023 to August 2024, a prospective study was conducted on 108 patients diagnosed with clinical stage cT1-2N0M0 breast cancer. All patients underwent SLN scintigraphy with 99mTc-sulfur colloid followed by gamma probe-guided detection and intraoperative sentinel lymph node biopsy (SLNB). Intraoperative frozen section analysis and standard postoperative histopathology were performed on all retrieved SLNs. Results: The sentinel lymph node identification rate was 98.1%, with a mean number of 2.34 ± 1.6 SLNs detected per patient. Tumor size and histological grade did not significantly influence the SLN detection rate. The sensitivity of the gamma probe-guided SLN detection technique was 95.2%. There was a high concordance (97.2%) between intraoperative frozen section results and standard histopathological findings. Conclusion: Sentinel lymph node scintigraphy using Technetium-99m labeled sulfur colloid with gamma probe guidance demonstrates high detection and sensitivity rates and is a reliable technique in breast cancer surgery.
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Keywords
Breast cancer, sentinel lymph node scintigraphy, gamma probe, sentinel lymph node biopsy
References
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