Article Sidebar
Views pdf: 116
EFFICACY OF HbA1C AND LIPID CONTROL AFTER 3 MONTHS OF STATIN USE IN PATIENTS WITH TYPE 2 DIABETES AT HUE UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL
Main Article Content
Abstract
Background: Dyslipidemia is a major cardiovascular risk factor in patients with type 2 diabetes. Statins are the drug of choice, yet their effects on glycemic control remain controversial. Methods: A prospective, descriptive–analytical study on 40 patients with type 2 diabetes receiving 10mg statin therapy at Hue University of Medicine and Pharmacy Hospital. HbA1C and lipid profiles were measured before and after 3 months. Linear regression was used to identify related factors. Results: Mean HbA1C decreased by 1.07% (p < 0.001), LDL-C decreased by 0.86 mmol/L (p < 0.001). Baseline HbA1C, ΔLDL-C and MMAS-8 score significantly affected ΔHbA1C. Greater LDL-C reduction was found in patients with higher initial LDL, lower BMI, higher education, and better adherence. Conclusion: Low-dose statins improve both HbA1C and lipid levels after 3 months. Emphasis should be placed on adherence and personalized factors to optimize outcomes.
Article Details
Keywords
Type 2 diabetes, statin, HbA1C, LDL-C, medication adherence
References
2. Nguyễn Văn Tuấn. Tình hình mắc bệnh đái tháo đường ở Việt Nam. Tạp chí Nội tiết & Đái tháo đường Việt Nam. 2020;25(4):203–209.
3. Trần Thị Hồng. Tỷ lệ rối loạn lipid máu ở bệnh nhân ĐTĐ típ 2. Y học TP.HCM. 2021;25(2):155–162.
4. American Diabetes Association. Standards of Medical Care in Diabetes—2023. Diabetes Care. 2023;46(Suppl 1):S1–S291.
5. Yamada T, et al. Effects of statins on glycemic control in patients with diabetes mellitus: a systematic review and meta-analysis. Cardiovasc Diabetol. 2023;22(1):101.
6. Nguyễn Thị Hương. Hiệu chỉnh thang đo MMAS-8 tiếng Việt và ứng dụng trong nghiên cứu tuân thủ thuốc điều trị. Tạp chí Y học Thực hành. 2017;11(1043):123–127.
7. Kastelein JJP, et al. ROSE2 study: Obicetrapib in combination with statins. N Engl J Med. 2024;390:1124–1132.
8. Rattanasompattikul M, et al. Statins and glycemic control in Thai diabetic population. Diab Res Clin Pract. 2022;190:110038.
9. Wang W, et al. Statin adherence and outcomes in Asia: real-world data. Diabetes Care. 2021;44(6):1340–1347.
10. Zhang H, et al. Predictors of LDL-C goal attainment among patients on statins. Am J Cardiol. 2022;182:1–8.