CÁC YẾU TỐ NGUY CƠ TIẾN TRIỂN TỔN THƯƠNG THẬN Ở TRẺ EM MẮC BỆNH SCHӦNLEIN – HENOCH

Abstract

Background: Accurate assessment and prognosis of renal involvement progression in patients with Henoch–Schönlein Purpura (HSP) is essential, enabling clinicians to establish appropriate monitoring strategies and tailored treatment plans for each patient, and to avoid overlooking serious complications. Objective: To identify risk factors for the progression of renal involvement in children with HSP. Methods: A prospective descriptive study was conducted on 45 patients from June 2024 to May 2025. Data were analysed using SPSS version 20.0. Results: Among the 45 patients enrolled in the study, 14 (31.1%) developed renal involvement within 6 months of disease onset. The risk factors significantly associated with progression included: initial involvement of three or more organ systems (combined type), prolonged purpura duration (≥ 30 days), gastrointestinal bleeding at disease onset, abnormal urinary protein/creatinine ratio, or presence of hematuria. Multivariate linear regression analysis showed that purpura duration was an independent factor significantly associated with the urinary protein/creatinine ratio after 6 months. Conclusion: HSP tends not to be a self-limiting disease and may progress to renal involvement or severe kidney disease in some patients. Clinicians should pay particular attention to children with HSP who present with these risk factors, as they are more likely to develop renal complications.