ĐẶC ĐIỂM THÔNG KHÍ NHÂN TẠO VÀ KẾT CỤC ĐIỀU TRỊ Ở BỆNH NHÂN ARDS MỨC ĐỘ TRUNG BÌNH, NẶNG

Abstract

Background: Patients with Acute Respiratory Distress Syndrome (ARDS) have a high mortality rate, posing a clinical challenge. In Vietnam, there are still limitations in detailed studies describing the characteristics of mechanical ventilation in ARDS patients, especially among those with moderate to severe levels. Objectives: To describe the characteristics of mechanical ventilation and treatment outcomes for patients with Acute Respiratory Distress Syndrome treated in Critical care Department of Chợ Rẫy Hospital. Methods: This is a prospective observational study. Inclusion criteria included patients diagnosed with moderate to severe ARDS according to the Berlin definition of 2012, who required invasive mechanical ventilation and were admitted to the Critical care Department of Chợ Rẫy Hospital. Results: Patients with ARDS were set with a median PEEP level of 10 (8 – 10) cmH₂O, and a median FiO₂ of 60 (51.5 – 80) %. The mean plateau pressure (P_plat) was 26.4 ± 3.25 cmH₂O. The median respiratory system compliance (C_rs) was 23.8 (19.7 – 27.7) mL/cmH₂O. The longest hospital stay was 68 days, while the shortest was 4 days. The median duration of Critical care Department stay was 13.5 (10 – 21) days, with a minimum of 4 days and a maximum of 30 days. The median duration of mechanical ventilation was 12 (8.25 – 19.5) days, ranging from 4 to 30 days. Out of 46 patients, 15 (32.6%) died in the Critical care Department, and 3 (6.5%) died outside the Critical care Department. The total in-hospital mortality rate was 18/46 (39.1%). Conclusions: Patients with moderate to severe ARDS were primarily set with high PEEP levels. The overall mortality rate in this group of patients was 32.6%.