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STUDY ON TOTAL SERUM IGE LEVELS IN PATIENTS WITH ATOPIC DERMATITIS AT NGHE AN GENERAL FRIENDSHIP HOSPITAL
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Abstract
Objective: This study aimed to investigate total serum IgE concentration and evaluate their association with disease severity in adult patients with atopic dermatitis. Subjects and Methods: A cross-sectional descriptive study was conducted on 130 patients aged 18 years and older, diagnosed with atopic dermatitis according to the American Academy of Dermatology (AAD) criteria, and treated at Nghe An General Friendship Hospital from October 2024 to March 2025. Total IgE serum concentration were measured using the Cobas 8000 analyzer. Disease severity was assessed using the Eczema Area and Severity Index (EASI). Data were analyzed using SPSS version 26.0. Results: Elevated total serum IgE concentration were observed in 86.9% of patients, with a mean value of 418 ± 215.77 IU/mL. The mean EASI score was 14.76 ± 10.59. Mean IgE concentration increased with disease severity: mild (231.42 ± 122.09 IU/mL), moderate (426.01 ± 151.92 IU/mL), and severe (679.05 ± 144.8 IU/mL), with statistically significant differences (p < 0.01). A strong positive correlation was found between total IgE concentration and EASI scores (rho = 0.834; p < 0.01). Patients with a family history of allergic diseases and those who smoked had significantly higher IgE levels (p < 0.05). Conclusion: The findings indicate that elevated total serum IgE concentration are common in patients with atopic dermatitis and are closely associated with disease severity. The strong correlation between IgE levels and EASI scores suggests that total IgE may serve as a useful biomarker for assessing disease severity in clinical practice. This study contributes additional evidence supporting the use of total IgE measurement in the comprehensive management and monitoring of atopic dermatitis.
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Keywords
Atopic dermatitis, total IgE serum concentration, EASI scores, disease severity
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