SO SÁNH PHƯƠNG PHÁP ĐỊNH LƯỢNG TRỰC TIẾP VÀ GIÁN TIẾP LDL-CHOLESTEROL Ở NGƯỜI BỆNH CÓ TRIGLYCERIDES ≤ 4,5 MMOL/L: HIỆU QUẢ CỦA CÁC CÔNG THỨC GIÁN TIẾP TẠI BỆNH VIỆN ĐA KHOA QUỐC ÁNH

Abstract

Objective: This study to evaluate the characteristics of dyslipidemia and the correlation between directly measured LDL-Cholesterol (LDL-C) and LDL-C estimated by indirect formulas (Friedewald, de Cordova, Anandaraja) in patients with triglyceride (TG) levels ≤ 4,5 mmol/L. Subjects and Methods: A cross-sectional study was conducted on test samples and medical records of 1.352 patients visiting Quoc Anh General Hospital in 2023, divided into Group I (TG ≤ 3,37 mmol/L) and Group II (3,37 < TG ≤ 4,50 mmol/L). LDL-C was measured directly using the AU640 analyzer and estimated using three indirect formulas (Friedewald, de Cordova, Anandaraja). Pearson correlation coefficient (r) was used to assess the correlation between methods. Results: The prevalence of dyslipidemia progressively increased with rising triglyceride concentrations, with LDL-C levels ≥ 3,4 mmol/L observed in 35,5% of Group I and 39,7% of Group II. The Pearson correlation coefficient (r) between directly measured and indirectly estimated LDL-C was notably high in Group I (de Cordova: r = 0,882) and comparatively lower in Group II (Friedewald: r = 0,651). Conclusion: The de Cordova formula is optimal when triglyceride levels are ≤ 3,37 mmol/L, while the Friedewald formula is suitable for TG levels between 3,37 and 4,50 mmol/L. Indirect formulas can serve as alternatives to direct measurement in patients with TG ≤ 4,5 mmol/L, helping to reduce testing costs.