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Date Published: 18/07/2025
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DOI: https://doi.org/10.51298/vmj.v552i1.14925
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Vol. 552 No. 1 (2025)
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Các bài báo
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Nguyễn, M., & Nguyễn Việt, H. (2025). THE LEVEL OF GROWTH FACTORS RELEASING FROM ADVANCED PLATELET-RICH FIBRIN IN THE TREATMENT OF PERIODONTAL INTRABONY DEFECTS. Vietnam Medical Journal, 552(1). https://doi.org/10.51298/vmj.v552i1.14925

THE LEVEL OF GROWTH FACTORS RELEASING FROM ADVANCED PLATELET-RICH FIBRIN IN THE TREATMENT OF PERIODONTAL INTRABONY DEFECTS

Mẹo Nguyễn, Hà Nguyễn Việt

Main Article Content

Abstract

Purpose: The aim of the study is to evaluate the level of growth factors (GFs) PDGF, VEGF and TGF-β1 in gingival crevicular fluid releasing from platelet-rich fibrin (A-PRF) in the treatment of periodontal intrabony defects. Materials and methods: 46 intrabony defects of 23 patients were randomly divided into 2 groups: test group (with A-PRF) and control group (without A-PRF). Gingival crevicular fluid was collected and assessed for PDGF, VEGF and TGF-β1 at baseline and 1, 3, 7, 14, 21, 30 postoperative days. Result: The level of GFs (PDGF-BB, VEGF and TGF-β1) in the test group was statistically higher than in the control at the early stage (day 1, day 3). At the time points of days 7, 14, 21 and 30 the difference was not significant (p>0.05). The concentration of GFs was similar in both groups: highest on day 1 after surgery and gradually decreased until day 30. Conclusion: GFs in gingival crevicular fluid were increased in the early stages of using advanced platelet-rich fibrin in the treatment of periodontal intrabony defects, might provide potential advantages for periodontal tissue regeneration.

Article Details

Keywords

periodontal intrabony defects, advanced platelet-rich fibrin, growth factors, gingival crevicular fluid

References

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