TIẾN TRIỂN CỦA SCHöNLEIN - HENOCH THỂ BỤNG Ở TRẺ EM

Abstract

Background: Henoch - Schönlein pupura (HSP) is a systemic vasculitis with inflammatory lesions by the deposition of IgA - containing immune complex in the wall of  small blood vessel. HSP characterized by nonthrombocytopenic palpable purpura, arthritis and abdominal pain. Gastrointestinal involvement (GI) is common and causes of HSP hospitalization. HSP is typically good prognosis, but some patients develop severe complications as gastrointestinal bleeding or glomerulonephritis. Methods: It was a case series study in 134 childrens with the first diagnosis of gastrointestinal involvement of  HSP admitted to National  Children's Hospital from 7/ 2020 to 6/ 2021  and extended for 3 months follow- up. Results: The median age of  HSP was 7 years old. Abdominal pain in 100% cases.  GI symptoms occurred before the manifestation of skin lession in 35,8% cases. Severe complications included gastrointestinal bleeding (44%), intussusception and  acute pancreatitis. Overall outcome were good with  self- limited  in 1 to 4 weeks. Renal involvement  often  occurred  during  1week to 1 month afer the disease onset. After 3 months, renal involvement decreased. Relapses occurred in 28,4% children. Conclusions: The overall outcome of GI involvement in children with HSP remains good. However,  children  with HSP should perform urinalysis regulary for early protection of complication.