NON-SPECIFIC CHRONIC INFLAMMATORY PRESENTATIONS ASSOCIATED WITH FOOD IN PEDIATRIC PATIENTS: A CASE REPORT

Hoàng Minh Khôi Phạm, Hoàng Dung Nguyễn, Thanh Bình Huỳnh

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Abstract

We report the case of a 10-year-old girl with a history of chronic diarrhea beginning at 10 months of age, accompanied by recurrent hypokalemia. More recently, she developed episodes of polyarthritis with prolonged fever. Laboratory investigations revealed markedly elevated inflammatory markers. Allergy testing for common allergens via IgE-mediated mechanisms yielded negative results; however, specific food items elicited high IgG-mediated responses. The patient was placed on an elimination diet excluding the identified intolerant foods, which led to significant improvement in gastrointestinal, joint, and nutritional symptoms. This case underscores the potential role of non-IgE-mediated food hypersensitivity in chronic inflammatory conditions.

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References

1. Boyce JA, Assa'ad A, Burks AW, et al. Guidelines for the Diagnosis and Management of Food Allergy in the United States: Summary of the NIAID-Sponsored Expert Panel Report. J Allergy Clin Immunol. 2010 Dec;126(6):1105-18. doi: 10.1016/j.jaci.2010.10.008. PMID: 21134568; PMCID: PMC4241958.
2. Gargano D, Appanna R, Santonicola A, et al. Food Allergy and Intolerance: A Narrative Review on Nutritional Concerns. Nutrients. 2021; 13(5):1638. https://doi.org/10.3390/nu13051638
3. Liccardi, G.; Caminati, M.; Senna, G.; Calzetta, L.; Rogliani, P. Anaphylaxis and intimate behaviour. Curr. Opin Allergy Clin. Immunol. 2017, 17, 350–355. [Google Scholar] [CrossRef]
4. Vita AA, Zwickey H, Bradley R. Associations between food-specific IgG antibodies and intestinal permeability biomarkers. Front Nutr. 2022 Sep 6;9:962093. doi: 10.3389/ fnut.2022. 962093. PMID: 36147305; PMCID: PMC9485556.
5. Gocki J, Bartuzi Z. Role of immunoglobulin G antibodies in diagnosis of food allergy. Postepy Dermatol Alergol. 2016 Aug;33(4):253-6. doi: 10.5114/ada.2016.61600. Epub 2016 Aug 16. PMID: 27605894; PMCID: PMC5004213.
6. Bellanti JA. IgE and non-IgE food allergy: A review of immunological mechanisms. J Food Allergy. 2024 Jul 1;6(1):37-46. doi: 10.2500/ jfa.2024.6.240003. PMID: 39257598; PMCID: PMC11382766.
7. Wolf WA, Jerath MR, Sperry SL, Shaheen NJ, Dellon ES. Dietary elimination therapy is an effective option for adults with eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2014 Aug;12(8): 1272-9. doi: 10.1016/j.cgh.2013. 12.034. Epub 2014 Jan 17. PMID: 24440337; PMCID: PMC4102669.