ĐẶC ĐIỂM ACID URIC MÁU VÀ CÁC YẾU TỐ LIÊN QUAN Ở BỆNH NHÂN LỌC MÁU CHU KỲ TẠI BỆNH VIỆN ĐA KHOA HOÈ NHAI

Abstract

Objectives: 1. To investigate serum uric acid levels in maintenance hemodialysis patients at Hoe Nhai General Hospital. 2. To evaluate the association between serum uric acid levels and the clinical manifestations as well as paraclinical parameters in these patients. Subjects and Methods: A cross-sectional descriptive study was conducted on 74 maintenance hemodialysis patients at Hoe Nhai General Hospital from November 2024 to March 2025. Results: The prevalence of hyperuricemia was 91.8%, with a mean serum uric acid level of 506.3 ± 99.3 µmol/L. No significant association was found between serum uric acid levels and age, gender, reuse frequency of dialyzers, residual urine volume, hemoglobin, serum albumin, phosphorus, or parathyroid hormone (PTH) levels. However, serum uric acid levels were significantly associated with hypertension status, body mass index (BMI), and the duration of dialysis. A moderate positive correlation was observed between serum uric acid and blood urea nitrogen (BUN) and creatinine levels (r = 0.563 and r = 0.483, respectively; p<0.05). A strong positive correlation was also found between the urea reduction ratio (URR) and the percentage reduction in serum uric acid after dialysis (r = 0.771). Conclusions: Hyperuricemia was highly prevalent among maintenance hemodialysis patients and was closely associated with BMI, dialysis duration, and blood levels of urea and creatinine. Serum uric acid was effectively removed through the hemodialysis process. Therefore, optimizing nutritional management, selecting appropriate dialyzers, and ensuring effective dialysis regimens could improve patients’quality of life and longevity.