XÉT NGHIỆM ĐỊNH LƯỢNG NỒNG ĐỘ LDL-CHOLESTEROL: HIỆU QUẢ CỦA CÁC CÔNG THỨC GIÁN ƯỚC TÍNH Ở NGƯỜI BỆNH CÓ TRIGLYCERIDE CAO

Abstract

Objective: This study aimed to assess the characteristics of dyslipidemia and the correlation between directly measured low-density lipoprotein cholesterol (LDL-C) and LDL-C estimated using indirect formulas (Friedewald, de Cordova, Anandaraja and Sampson) in patients with triglyceride (TG) levels exceeding 4,5 mmol/L. Subjects and Methods: A cross-sectional study was conducted on laboratory samples and medical records of 801 patients who visited Quoc Anh General Hospital in 2023. Participants were divided into two groups: Group IIIA (4,50 < TG ≤ 7,0 mmol/L) and Group IIIB (7,0 < TG ≤ 15,0 mmol/L). LDL-C was measured directly using the AU640 analyzer and estimated by four indirect formulas (Friedewald, de Cordova, Sampson and Anandaraja). Pearson’s correlation coefficient (r) was employed to evaluate the correlation between the methods. Results: The correlation coefficient rrr between directly and indirectly measured LDL-C is low. All four formulas yield a correlation coefficient r<0,5 in groups IIIA and IIIB. Specifically, the correlation coefficients between direct measurement and the Friedewald, de Cordova, Anandaraja and Sampson formulas in group IIIA are 0,360; 0.366; 0,404, and 0,364, respectively, while in group IIIB, they are 0,280; 0.416; 0,270 and 0,307, respectively. Conclusion: Indirect formulas lack reliability when TG levels exceed 4,5 mmol/L. The direct measurement method should be utilized to ensure accuracy.