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EVALUATION OF RENAL FUNCTION CHANGES IN HEPATOCELLULAR CARCINOMA PATIENTS AFTER TRANSARTERIAL CHEMOEMBOLIZATION
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Abstract
Objective: To evaluate changes in renal function in patients with hepatocellular carcinoma (HCC) after treatment with transarterial chemoembolization (TACE). Methods: A prospective analysis comparing renal function before and after TACE in 80 patients with HCC. Results: The average age was 61.48±12.36 years, with males accounting for 87.5%. Hepatitis B infection was present in 77.5% of patients. Child-Pugh class A was observed at 98.8%, and Kinki stage B2 in 58.8%. Pre-treatment AFP levels were below 200 ng/mL in 61.2% of patients. After TACE, blood urea levels decreased from 5.01±1.57 to 4.50±1.65 mmol/L (p=0.004); creatinine and estimated glomerular filtration rate (eGFR) showed no significant changes (p>0.05). A decrease in eGFR was observed in 51.3% of patients, with 42.5% showing a reduction of less than 25% and 8.8% a reduction of ≥25%. The lowest eGFR recorded after TACE was 75.1 mL/min/1.73m2. Conclusion: TACE caused a decrease in eGFR in 51.3% of patients with intermediate-stage HCC, with a significant reduction (≥25%) in 8.8% of cases. Close monitoring of renal function after TACE is essential to minimize the risk of long-term kidney damage.
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Keywords
change in glomerular filtration rate, Hepatocellular carcinoma, transarterial chemoembolization
References
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