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Date Published: 12/08/2025
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DOI: https://doi.org/10.51298/vmj.v552i3.15086
Issue
Vol. 552 No. 3 (2025)
Section
Các bài báo
How to Cite
Trần Duy, H., & Đinh Thị Ánh, N. (2025). EVALUATION OF THE EFFICACY OF HELICOBACTER PYLORI ERADICATION USING HIGH-DOSE AMOXICILLIN AND PPI IN PATIENTS WITH BLEEDING DUODENAL ULCERS. Vietnam Medical Journal, 552(3). https://doi.org/10.51298/vmj.v552i3.15086

EVALUATION OF THE EFFICACY OF HELICOBACTER PYLORI ERADICATION USING HIGH-DOSE AMOXICILLIN AND PPI IN PATIENTS WITH BLEEDING DUODENAL ULCERS

Hưng Trần Duy, Nguyệt Đinh Thị Ánh

Main Article Content

Abstract

Objectives: Evaluation of the efficacy of Helicobacter pylori eradication using high-dose Amoxicillin and PPI in patients with bleeding duodenal ulcers. Subjects and methods: Patients with duodenal ulcer complicated by gastrointestinal bleeding and positive for H. pylori (HP+) who were diagnosed and treated at the Department of Gastroenterology – Bach Mai Hospital. Results: The H. pylori eradication rate of the regimen was 66.7% (per-protocol) and 60.5% (intention-to-treat). These rates did not meet the target for successful H. pylori eradication. There was a significant difference in H. pylori eradication rates based on patients' smoking history (p < 0.05), with non-smokers having higher eradication rates compared to smokers (ITT: 69.7% vs. 30%; PP: 76.7% vs. 33.3%). The ulcer healing rate after H. pylori eradication treatment was 74.4%, while the non-healing rate was 25.6%. Conclusions: A high-dose Amoxicillin and proton pump inhibitor (PPI) regimen is among the effective therapeutic strategies for Helicobacter pylori eradication in patients with bleeding duodenal ulcers.

Article Details

Keywords

Helicobacter pylori (HP), ITT: Intention to treat và PP: Per protocol, GI bleeding

References

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