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Issue: Vol. 552 No. 3 (2025)
Section: Các bài báo
DOI: 10.51298/vmj.v552i3.15086
Date Published: 12/08/2025
Views 530
Downloads 360
How to Cite
Trần Duy, H., & Đinh Thị Ánh, N. (2025). EVALUATION OF THE EFFICACY OF HELICOBACTER PYLORI ERADICATION USING HIGH-DOSE AMOXICILLIN AND PPI IN PATIENTS WITH BLEEDING DUODENAL ULCERS. Vietnam Medical Journal, 552(3). https://doi.org/10.51298/vmj.v552i3.15086

EVALUATION OF THE EFFICACY OF HELICOBACTER PYLORI ERADICATION USING HIGH-DOSE AMOXICILLIN AND PPI IN PATIENTS WITH BLEEDING DUODENAL ULCERS

Hưng Trần Duy , Nguyệt Đinh Thị Ánh

Main Article Content

Abstract

Objectives: Evaluation of the efficacy of Helicobacter pylori eradication using high-dose Amoxicillin and PPI in patients with bleeding duodenal ulcers. Subjects and methods: Patients with duodenal ulcer complicated by gastrointestinal bleeding and positive for H. pylori (HP+) who were diagnosed and treated at the Department of Gastroenterology – Bach Mai Hospital. Results: The H. pylori eradication rate of the regimen was 66.7% (per-protocol) and 60.5% (intention-to-treat). These rates did not meet the target for successful H. pylori eradication. There was a significant difference in H. pylori eradication rates based on patients' smoking history (p < 0.05), with non-smokers having higher eradication rates compared to smokers (ITT: 69.7% vs. 30%; PP: 76.7% vs. 33.3%). The ulcer healing rate after H. pylori eradication treatment was 74.4%, while the non-healing rate was 25.6%. Conclusions: A high-dose Amoxicillin and proton pump inhibitor (PPI) regimen is among the effective therapeutic strategies for Helicobacter pylori eradication in patients with bleeding duodenal ulcers.

Keywords

Helicobacter pylori (HP), ITT: Intention to treat và PP: Per protocol, GI bleeding

Article Details

References

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