KHẢO SÁT TÌNH TRẠNG NHIỄM HUMAN PAPILLOMAVIRUS NGUY CƠ CAO Ở PHỤ NỮ CÓ TỔN THƯƠNG LOẠN SẢN BIỂU MÔ VẢY CỔ TỬ CUNG

Abstract

Objectives: This study aims to assess the prevalence of high-risk Human papillomavirus (hrHPV) infection and the association of HPV 16 and 18 with high-grade squamous intraepithelial lesions (HSILs). Methods: The cross-sectional study included 470 patients who visited Hanoi Medical University Hospital from March 2023 to October 2024. All patients underwent hrHPV testing and cervical biopsies. The statistical analysis was performed using SPSS version 26.0 for Windows. Results and conclusion: The prevalence of hrHPV infection among women with CIN was 94.0%. Among these cases, 42.6% were infected with either HPV 16 or 18. HPV 16 and 18 were detected in CIN 1, CIN 2, CIN3 lesions with rates of 24.9%, 37.3%, 54.5% and 15.7%, 14.9%, 15.2%, respectively. HPV type 16 is the most common type (30.4%), the presence of HPV type 16 increases the risk of CIN 3 by 3.2 times compared to CIN 1 (OR = 3,200, CI: 1,861 – 5,503, p < 0.01).