NGHIÊN CỨU MỐI LIÊN QUAN GIỮA APOLIPOPROTEIN B ĐẾN KẾT CỤC LÂM SÀNG NỘI VIỆN TRÊN BỆNH NHÂN CAO TUỔI HỘI CHỨNG VÀNH CẤP

Abstract

Background: the prognostic value of Apolipoprotein B (Apo B) for in-hospital mortality in elderly patients with acute coronary syndrome is a topic of growing clinical interest. However, relevant data in the Vietnamese population remain limited. Objective: to investigate the association between Apo B levels and in-hospital clinical outcomes in elderly patients with acute coronary syndrome. Subjects and Methods: this was a descriptive cross-sectional study. The study population included patients aged ≥ 60 years who were admitted with a diagnosis of acute coronary syndrome and underwent coronary angiography confirming significant coronary artery disease, from August 2024 to June 2025, at the Department of Emergency and Interventional Cardiology, Thong Nhat Hospital. Results: a total of 337 patients were enrolled. The mean age was 70.1 ± 7.3 years, with males accounting for 65.9%. The median Apo B level was 96.2 mg/dL (IQR: 86.2 - 116.8). Multivariate analysis revealed that patients with elevated Apo B levels had a 3.2-fold higher risk of in-hospital mortality compared to those with lower Apo B levels (OR = 3.2; 95% CI: 1.1 - 11.4; p = 0.04). In addition, age ≥ 80 years and Killip class III - IV were also identified as independent predictors of mortality. Conclusions: Apo B is an independent prognostic factor associated with increased in-hospital mortality in elderly patients with acute coronary syndrome.