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INDICATIONS AND OUTCOMES OF THERAPEUTIC PLASMA EXCHANGE FOR CHILDREN AT VIETNAM NATIONAL CHILDREN’S HOSPITAL
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Abstract
Background: Therapeutic Plasma Exchange (TPE) is a vital therapeutic modality and has been used in Pediatric Intensive Care Units for a wide spectrum of diseases. Objective: To describe the indications for TPE and outcomes of TPE in children. Study population and Methods: A retrospective descriptive study including 71 pediatric patients undergoing 276 TPE episodes from January 2017 to June 2023 at Vietnam National Children's Hospital. Results: Among the patients requiring TPE, liver failure accounted for the highest proportion (43.7%), followed by neuromuscular disorders (36.6%). Overall mortality rate was 33.8%. Procedural complications were detected in 26.4% in total 276 TPE procedures. Conclusions: TPE is well-tolerated in pediatric patients and can be implemented according to the guidelines of the American Society for Apheresis (ASFA). Further standardization of indications and technical aspects of TPE in children is crucial to optimize efficacy and minimize complications in patients.
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Keywords
Therapeutic Plasma Exchange (TPE), children, indication, outcomes
References
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