GIÁ TRỊ PLGF TRONG SÀNG LỌC TIỀN SẢN GIẬT Ở BA THÁNG ĐẦU THAI KỲ

Abstract

Objective: Evaluation of PlGF concentration and median value at 11, 12, and 13 weeks of gestation and assess the abnormality rate of PlGF in the first trimester of pregnancy. Subjects and Methods: Pregnant women between 11 and 13 weeks and 6 days of gestation were indicated to undergo PlGF testing as part of the preeclampsia risk screening program from February 2025 to May 2025 at Hung Vuong Hospital in Ho Chi Minh City. Serum samples were collected and PlGF was quantified on the Roche - Cobas e801 system using electrochemiluminescence technology. Data were analyzed using IBM SPSS Statistics 27. Results: The median PlGF and interquartile range (IQR) for gestational weeks 11, 12, and 13 were 40.80 pg/ml (32.20 – 52.30), 51.40 pg/ml (38.10 – 65.75), and 68.10 pg/ml (49.68 – 79.13), respectively. There was no significant difference in median MoM PlGF among maternal age groups. The rates of cases with low PlGF according to the thresholds MoM < 0.3, MoM < 0.4, and MoM < 0.5 were 1.36%, 4.47%, and 10.10%, respectively, with no significant differences in these rates among maternal age and among gestational age groups. Conclusion: PlGF levels increase progressively from week 11 to week 13 of pregnancy. There is a difference in the median PlGF values between Vietnamese pregnant women and other Asian ethnicities. The proportion of pregnant women with MoM PlGF < 0.5 is approximately 10%, evenly distributed across gestational weeks and maternal age groups.